Resolor prucalopride Review

Resolor Prucalopride Review | 4 Months on

So, I thought that now is a good time for me to do another update on my experience taking Resolor (Prucalopride).

If you haven’t read my previous posts regarding Resolor, please do. It will help you to understand the ups and downs I had when I first started to take it.

It’s been 4 months since I started taking Resolor and I’m so happy to report that my chronic constipation is now no longer a chronic problem. I have a bowel movement almost every day or every 3 days which is “apparently” normal (wow…I’m normal…that sounds boring but I think I’m OK with that). I still don’t get the sensation to go to the bathroom but if I sit on the toilet and push I do manage to have a BM.

I take my Resolor every morning just before breakfast and usually straight after, I get a little metallic taste but nothing too powerful, and that usually passes after a couple of hours. I don’t get stomach pains or notice any serious side affects. I can now feel my bowel working and moving which is a good sign and I don’t feel full after I eat. Now that I’m going to the bathroom often I lose weight so easily as my metabolism has sped up, but I have learnt to adjust my caloric intake. I drink 2 litres of water everyday to help hydrate my bowel and keep my stools soft. I exercise for 30min everyday to also strengthen my stomach muscles. I also stick rigidly to a low FODMAP diet for now which helps my IBS and stop inflammation in my bowel as that can cause constipation and diarrhea.

All these little lifestyle changes have proven effective in my fight to get my body into a routine of working how it should. I’m now learning for the first time in my life to have a ‘somewhat’ natural BM. My poor Fiance has to put with me asking quite personal questions but he’s amazingly supportive and I know I couldn’t do it without him.

The only time I can get quite constipated is during and after my period. This is due to sudden fluctuation in my hormones and I usually know that no matter how good my diet is I will still get constipated.


I think the hardest adjustment is my psychological acceptance of not always being constipated. I’ve lived for 28 years with the stress and worry of not having bowel movements. I have recently been battling with my mind to just relax and I keep telling myself that you don’t have to worry about it anymore. For a while I felt like I was always forgetting something; the same feeling you get when you leave your house and you feel like you forgot your keys. This has been the hardest for me to come to terms with. It’s like losing something that had always been there, it was what I knew, a comfort, as it was normality; when you learn to ride a bike for the first time and your dad takes your training wheels off “That’s it kid, your in control now!” It’s scary but over time I have been building my confidence and putting trust in my body to do what it needs to and not depend on laxatives.

I still see it as a long road ahead but I’m over the worst of it and there have been tears of joy and tears of frustration. But the love and support of my Fiance has kept me strong. Thank you Andy X


Please note:

Please remember I'm not a doctor of any kind and the information on this site is advisory only, you must always consult a qualified physician prior to dramatic lifestyle changes or if you have any cause for concern about your own well-being.

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21 Responses to Resolor Prucalopride Review | 4 Months on

  1. Janni May 22, 2015 at 11:51 pm #

    Hey Katie
    You have no idea how comforting it is, to read your letter of experience.
    I just started this week taking Resolor, and I am having some side effects.
    I feel sick all the time, my stomach hurts.
    Sure hope it will get better soon, and I hope for results so that I no longer will be constipated.
    You even mention that your metabolism has got better. How great- I had given Up on loosing any weight. Thank you for giving me hope for my future 🙂

  2. mary January 3, 2017 at 4:50 am #

    I have also been constipated with IBs-c bloating etc. for about 5 years now. Symptoms became chronic this year – was prescribed amitiza which was awful and then resolor.
    september – mid december was bliss -Bowel movement nearly every day (supplemented with magnesium oxide and digestive enzymes and probiotics which I now fear may have been making resolor redundant) .

    The last 3 weeks i have been so bunged up – bowel movement only with milk of magnesia overdose . I have been eating irregularly and no exercise due to christmas seasons and praying this is why. do you know if it is common for resolr to cease working?

    Feeling very despairing. thank you.

    • kate4health January 3, 2017 at 5:43 pm #

      Hi Mary and thank for commenting,

      I would definatly say that lack of exercise, over indulgence of sugar, meat, alcohol etc all play a large part in the cause of constipation and in turn can reduce the effectiveness of Resolor.

      However, don’t despair! A little exercise, plenty of water and making sure your eating nutrient dense foods should help increase your bowel movements. Remember constipation is only a symptom of an underlying problem and can be easily fixed with diet and exercise.

      Remember to continue to take your Resolor too.

      Happy New Year

  3. Tamar March 11, 2017 at 5:41 pm #

    Hi! Are you still taking resolor? I just started 2 days and seriously considering stopping as the side effects are insane. Like migraine and such intense nausea. How long do you need to take the medicine until bowel movements become regular? Or are you on it forever?
    Thank you ?

    • kate4health March 14, 2017 at 1:50 pm #

      Hi Tamar! The side effects are normal. It’s not harming you it’s just your body’s hormone levels adjusting. Give it a couple of days and you should start to feel better.

      It works straight away but remember its not a laxative, it just helps the body move things along.

      I would say yes, you may be on it forever unless your doctor stated otherwise. You may not be producing serotonin or you may not have the receptors to transport the serotonin to the bowel.

      A quick note: if you stop taking it for a while you may experience these symptoms again while your body adjusts back on it.


  4. Kerry June 30, 2017 at 2:16 pm #

    Hi there I’ve just started taking resolor, and omg I’ve been so poorly all night constantly being sick and constant runs and can’t keep off toilet the pain in my tummy is still so bad I’m considering going to hospital I’ve also got a very fast heart rate, feeling really poorly today xx

  5. Senna Wales August 6, 2017 at 2:13 pm #

    Hi Kate,

    I can’t tell you how many times I’ve read and re-read your blog. It’s such an important source of information, hope and inspiration for me! I’ve been taking Prucalopride for 7 months now, and I feel like it started to work slower and slower after the first two months. At first I started eating more salad greens and roughage to help move things along (I have anismus, PFD and colonic-inertia).

    TMI, I know, but I also took psyllium husk seeds to keep everything firm, because otherwise everything was coming out in practically liquid form (I thought things would get more firm, but when two months after I started taking Prucalopride, I was still getting loose, watery stools, so I started on the psyllium husk since I can’t even evacuate liquid stool–always difficult to explain to nurses before a colonoscopy!).

    Unfortunately, it got to the point where even having big salads and a kale smoothie a day wasn’t enough, so I turned to alternating coffee, dulcolax and magnesium citrate pills every other day (in conjunction with Prucalopride ) to be able to go. None of these methods work without prucalopride, so I have to take Prucalopride with another pill/drink to get things moving.

    What would you recommend? Prucalopride is expensive, and it’s barely working for me at this point. Should I try linzess or amitiza? My gastro is ready to prescribe them, but I keep wondering what I’m going to do when those two medications also stop working for me. I feel like I need to save them for surgery or some other future need (since the bowls stop working after surgery in normal people, and in my case, totally become dead).

    Do you still use Prucalopride or did it stop working for you? Please write an updated blog post. I’m sure I’m not the only open who wants to know!

    • kate4health August 12, 2017 at 3:29 pm #

      Hi Senna!

      Thanks so much for your lovely comment. It may feel like prucalodride slows or stops working; I have quite a few readers tell me they feel it is less effective than when they started taking it. I have also experience similar effects over the past years of taking it. However Prucalopride doesn’t really stop working. The body will use what it needs to and you excrete the rest. If you feel like diet is not working, try turning your attention to other factors. Stress can influence the effectiveness, not enough hours sleep or even a bacterial imbalance in the body can slow the gut which may feel like the medication is not working. Many of us with severely slow digestion are prone to bacterial imbalances in the body. Try taking a high quality probiotic to help regulate the good bacteria. If that doesn’t work try getting tested for SIBO (small Intestinal Bacterial Overgrowth) or candida. These are the biggest culprits I can think of another point is that if you are eating a low carb diet this will not help the situation. Try upping your carbs with a little white rice, oats and increase good fat content.

      Personally for me I also find exercise works wonders for me especially ab workouts as this strengthens your core that includes the muscles around your gut. Give it a go and see if it helps.

      I hope that helps & don’t despair, the good news is prucalopride worked for you initially which means your bowels are working they are just very sluggish 🙂

      All the best

  6. Fran October 14, 2017 at 6:41 pm #

    Hi Kate,

    I’ve just stumbled across your blog and so glad I have! Are you still getting on well with Prucalopride?

    I started it a couple of months ago and it as helped with bowels but I am still getting side effects of headache and nausea. I often wake up with a bad headache but I take it before bed so having seen you take it in the morning thought I might try this way. Have you always taken in the morning or noticed any difference if taking it at other times? My main concern of taking it in the morning is then needing to go to the toilet after I’ve left the house!

    • kate4health October 14, 2017 at 7:09 pm #

      Hi Fran,

      Thank you for your comment! Yes I’m still taking Prucalopride and yes I have always taken it in the morning. I understand your concern although I’ve never had a problem of needing to rush for the bathroom after taking it. I’m pretty sure headaches and nausea are normal but if you find it too much to bare I’d go back to your specialist and tell him. I don’t suffer with nausea or headaches on it but if I stop taking (which I have done in the past for up to a month) then I’ll get all the symptoms for maybe a day or so, while my body adjusts back on to it.

      I hope that helps
      Let me know if you have any further questions 🙂

      • Fran October 15, 2017 at 2:47 am #

        Thanks Kate, I guess I just have to try it and see! I will try it tomorrow in the morning when I don’t have to go out first thing. I don’t get any urgency straight after taking it at night but I just wondered if it’s effect might be more pronounced in the morning as that’s generally when the urge to go is strongest anyway just after breakfast.

        All the best

  7. shiralee October 28, 2017 at 9:29 am #

    Hi All , very interesting reading, I have had chronic constipation for years, if it snowballs end up with diverticulitis, which is awful. This all started when ii was about 20 after years of dieting, also had a bout of holiday tummy , ended up with years of chronic pain, sweating, headaches, lack of confidence, ( scared of having an accident at work) after taking over the counter remedies. Had many test, cameras here and there. My colon has become overstretched with pockets, due to the chronic constipation. I think the side effects of constipation are so depressing, Insomnia, back problems, lack of confidence, acid reflux, chronic pain in tummy when distended , all these things made worse by the menopause, I have been taking Prucalopride for a number of years, and yes your body does seem to become immune to it, it doesnt work well for me to be honest, my tummy often becomes so full , heavy and ready to explode, I also take peppermint capsules,soothing and slippery elm for the acid reflux, probiotic, walk my dog daily, work full time so on the go , try to keep happy, but it sounds dramatic but it is a daily struggle, fed up with it, and the constant fat belly, water retention, fuzzy head thanks for reading ,

  8. Sushma March 8, 2018 at 8:47 am #


    I read all of ur posts from starting till the last one , I have started taking resolor only from yesterday aft taking it immediately aft 2 hours I had loose stools and again n again some 4 times . This is not good I feel I mean how am I supposed to take this tab and go out if I keep having loose stools . I had to cancel important things coz of this . I am having constipation issues only since 1 year and it was not chronic only since 5-6 months it’s become hard cant pass without laxatives . But continuing resolor am not sure as it gives me loose stools n bad migraine for days together with jus 1mg of it

  9. Anto July 15, 2018 at 8:40 am #

    Love to hear replies. Love this blog.

  10. Dora Mortimer Heath July 21, 2018 at 7:10 am #

    Researching Resolor to discuss with my Gastro doctor. I have Celiac Disease and Gastroparesis. I am 54 years old and had a complete hysterectomy April 3, 2018.
    The Bloating, Gas and Constipation and Nausea have gotten worse since the hysterectomy. I have been using Dulcolax ,
    Stool Softners, Phazyme, heat pads for my stomach area and ice packs for lower back.
    I am concern about staying sick with Nausea and Migraine. Please advise.
    Thank You-D. HEATH

  11. Fran August 25, 2018 at 7:33 pm #

    Hi Again Kate,

    I just wondered how prucalopride is working for you now? I’ve been taking it for a year now and have a couple of issues which I think are caused by it. I wake up very early and my stomach in cramps because I’m hungry (despite having something to eat before bed) and also my hair seems to have been falling out since I started. Did you or do you experience either of these please? Has your weight stabilised too? Mine started going up which was concerning me!

  12. Fran August 27, 2018 at 7:17 am #

    Hi Again Kate,

    I just wondered how prucalopride is working for you now? I’ve been taking it for a year now and have a couple of issues which I think are caused by it. I wake up very early and my stomach in cramps because I’m hungry (despite having something to eat before bed) and also my hair seems to have been falling out since I started. Did you or do you experience either of these please? Has your weight stabilised too?

    • kate4health August 27, 2018 at 7:36 am #

      Hi Fran, I haven’t had any of these symptoms. I do get hungrier on it but that’s because it speeds up your digestion and as a result your metabolism. My weight is much easier to manage I fund too.

      I would see a doctor about your falling out, you may be lacking a nutrient.

      I hope that helps 😊

      All the Kate

      • Fran August 27, 2018 at 12:33 pm #

        Thanks Kate

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