Resolor prucalopride Review

Resolor Prucalopride Review | 4 Months on

So, I thought that now is a good time for me to do another update on my experience taking Resolor (Prucalopride).

If you haven’t read my previous posts regarding Resolor, please do. It will help you to understand the ups and downs I had when I first started to take it.

It’s been 4 months since I started taking Resolor and I’m so happy to report that my chronic constipation is now no longer a chronic problem. I have a bowel movement almost every day or every 3 days which is “apparently” normal (wow…I’m normal…that sounds boring but I think I’m OK with that). I still don’t get the sensation to go to the bathroom but if I sit on the toilet and push I do manage to have a BM.

I take my Resolor every morning just before breakfast and usually straight after, I get a little metallic taste but nothing too powerful, and that usually passes after a couple of hours. I don’t get stomach pains or notice any serious side affects. I can now feel my bowel working and moving which is a good sign and I don’t feel full after I eat. Now that I’m going to the bathroom often I lose weight so easily as my metabolism has sped up, but I have learnt to adjust my caloric intake. I drink 2 litres of water everyday to help hydrate my bowel and keep my stools soft. I exercise for 30min everyday to also strengthen my stomach muscles. I also stick rigidly to a low FODMAP diet for now which helps my IBS and stop inflammation in my bowel as that can cause constipation and diarrhea.

All these little lifestyle changes have proven effective in my fight to get my body into a routine of working how it should. I’m now learning for the first time in my life to have a ‘somewhat’ natural BM. My poor Fiance has to put with me asking quite personal questions but he’s amazingly supportive and I know I couldn’t do it without him.

The only time I can get quite constipated is during and after my period. This is due to sudden fluctuation in my hormones and I usually know that no matter how good my diet is I will still get constipated.


I think the hardest adjustment is my psychological acceptance of not always being constipated. I’ve lived for 28 years with the stress and worry of not having bowel movements. I have recently been battling with my mind to just relax and I keep telling myself that you don’t have to worry about it anymore. For a while I felt like I was always forgetting something; the same feeling you get when you leave your house and you feel like you forgot your keys. This has been the hardest for me to come to terms with. It’s like losing something that had always been there, it was what I knew, a comfort, as it was normality; when you learn to ride a bike for the first time and your dad takes your training wheels off “That’s it kid, your in control now!” It’s scary but over time I have been building my confidence and putting trust in my body to do what it needs to and not depend on laxatives.

I still see it as a long road ahead but I’m over the worst of it and there have been tears of joy and tears of frustration. But the love and support of my Fiance has kept me strong. Thank you Andy X


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56 Responses to Resolor Prucalopride Review | 4 Months on

  1. Janni May 22, 2015 at 11:51 pm #

    Hey Katie
    You have no idea how comforting it is, to read your letter of experience.
    I just started this week taking Resolor, and I am having some side effects.
    I feel sick all the time, my stomach hurts.
    Sure hope it will get better soon, and I hope for results so that I no longer will be constipated.
    You even mention that your metabolism has got better. How great- I had given Up on loosing any weight. Thank you for giving me hope for my future :-)

  2. mary January 3, 2017 at 4:50 am #

    I have also been constipated with IBs-c bloating etc. for about 5 years now. Symptoms became chronic this year – was prescribed amitiza which was awful and then resolor.
    september – mid december was bliss -Bowel movement nearly every day (supplemented with magnesium oxide and digestive enzymes and probiotics which I now fear may have been making resolor redundant) .

    The last 3 weeks i have been so bunged up – bowel movement only with milk of magnesia overdose . I have been eating irregularly and no exercise due to christmas seasons and praying this is why. do you know if it is common for resolr to cease working?

    Feeling very despairing. thank you.

    • kate4health January 3, 2017 at 5:43 pm #

      Hi Mary and thank for commenting,

      I would definatly say that lack of exercise, over indulgence of sugar, meat, alcohol etc all play a large part in the cause of constipation and in turn can reduce the effectiveness of Resolor.

      However, don’t despair! A little exercise, plenty of water and making sure your eating nutrient dense foods should help increase your bowel movements. Remember constipation is only a symptom of an underlying problem and can be easily fixed with diet and exercise.

      Remember to continue to take your Resolor too.

      Happy New Year

  3. Tamar March 11, 2017 at 5:41 pm #

    Hi! Are you still taking resolor? I just started 2 days and seriously considering stopping as the side effects are insane. Like migraine and such intense nausea. How long do you need to take the medicine until bowel movements become regular? Or are you on it forever?
    Thank you ?

    • kate4health March 14, 2017 at 1:50 pm #

      Hi Tamar! The side effects are normal. It’s not harming you it’s just your body’s hormone levels adjusting. Give it a couple of days and you should start to feel better.

      It works straight away but remember its not a laxative, it just helps the body move things along.

      I would say yes, you may be on it forever unless your doctor stated otherwise. You may not be producing serotonin or you may not have the receptors to transport the serotonin to the bowel.

      A quick note: if you stop taking it for a while you may experience these symptoms again while your body adjusts back on it.


  4. Kerry June 30, 2017 at 2:16 pm #

    Hi there I’ve just started taking resolor, and omg I’ve been so poorly all night constantly being sick and constant runs and can’t keep off toilet the pain in my tummy is still so bad I’m considering going to hospital I’ve also got a very fast heart rate, feeling really poorly today xx

    • Monique castleman December 19, 2020 at 4:12 pm #

      I’ve just started the meditation and suffering the same im not taking any more cant keep being unwell keeping me up all night

  5. Senna Wales August 6, 2017 at 2:13 pm #

    Hi Kate,

    I can’t tell you how many times I’ve read and re-read your blog. It’s such an important source of information, hope and inspiration for me! I’ve been taking Prucalopride for 7 months now, and I feel like it started to work slower and slower after the first two months. At first I started eating more salad greens and roughage to help move things along (I have anismus, PFD and colonic-inertia).

    TMI, I know, but I also took psyllium husk seeds to keep everything firm, because otherwise everything was coming out in practically liquid form (I thought things would get more firm, but when two months after I started taking Prucalopride, I was still getting loose, watery stools, so I started on the psyllium husk since I can’t even evacuate liquid stool–always difficult to explain to nurses before a colonoscopy!).

    Unfortunately, it got to the point where even having big salads and a kale smoothie a day wasn’t enough, so I turned to alternating coffee, dulcolax and magnesium citrate pills every other day (in conjunction with Prucalopride ) to be able to go. None of these methods work without prucalopride, so I have to take Prucalopride with another pill/drink to get things moving.

    What would you recommend? Prucalopride is expensive, and it’s barely working for me at this point. Should I try linzess or amitiza? My gastro is ready to prescribe them, but I keep wondering what I’m going to do when those two medications also stop working for me. I feel like I need to save them for surgery or some other future need (since the bowls stop working after surgery in normal people, and in my case, totally become dead).

    Do you still use Prucalopride or did it stop working for you? Please write an updated blog post. I’m sure I’m not the only open who wants to know!

    • kate4health August 12, 2017 at 3:29 pm #

      Hi Senna!

      Thanks so much for your lovely comment. It may feel like prucalodride slows or stops working; I have quite a few readers tell me they feel it is less effective than when they started taking it. I have also experience similar effects over the past years of taking it. However Prucalopride doesn’t really stop working. The body will use what it needs to and you excrete the rest. If you feel like diet is not working, try turning your attention to other factors. Stress can influence the effectiveness, not enough hours sleep or even a bacterial imbalance in the body can slow the gut which may feel like the medication is not working. Many of us with severely slow digestion are prone to bacterial imbalances in the body. Try taking a high quality probiotic to help regulate the good bacteria. If that doesn’t work try getting tested for SIBO (small Intestinal Bacterial Overgrowth) or candida. These are the biggest culprits I can think of another point is that if you are eating a low carb diet this will not help the situation. Try upping your carbs with a little white rice, oats and increase good fat content.

      Personally for me I also find exercise works wonders for me especially ab workouts as this strengthens your core that includes the muscles around your gut. Give it a go and see if it helps.

      I hope that helps & don’t despair, the good news is prucalopride worked for you initially which means your bowels are working they are just very sluggish :)

      All the best

  6. Fran October 14, 2017 at 6:41 pm #

    Hi Kate,

    I’ve just stumbled across your blog and so glad I have! Are you still getting on well with Prucalopride?

    I started it a couple of months ago and it as helped with bowels but I am still getting side effects of headache and nausea. I often wake up with a bad headache but I take it before bed so having seen you take it in the morning thought I might try this way. Have you always taken in the morning or noticed any difference if taking it at other times? My main concern of taking it in the morning is then needing to go to the toilet after I’ve left the house!

    • kate4health October 14, 2017 at 7:09 pm #

      Hi Fran,

      Thank you for your comment! Yes I’m still taking Prucalopride and yes I have always taken it in the morning. I understand your concern although I’ve never had a problem of needing to rush for the bathroom after taking it. I’m pretty sure headaches and nausea are normal but if you find it too much to bare I’d go back to your specialist and tell him. I don’t suffer with nausea or headaches on it but if I stop taking (which I have done in the past for up to a month) then I’ll get all the symptoms for maybe a day or so, while my body adjusts back on to it.

      I hope that helps
      Let me know if you have any further questions :)

      • Fran October 15, 2017 at 2:47 am #

        Thanks Kate, I guess I just have to try it and see! I will try it tomorrow in the morning when I don’t have to go out first thing. I don’t get any urgency straight after taking it at night but I just wondered if it’s effect might be more pronounced in the morning as that’s generally when the urge to go is strongest anyway just after breakfast.

        All the best

  7. shiralee October 28, 2017 at 9:29 am #

    Hi All , very interesting reading, I have had chronic constipation for years, if it snowballs end up with diverticulitis, which is awful. This all started when ii was about 20 after years of dieting, also had a bout of holiday tummy , ended up with years of chronic pain, sweating, headaches, lack of confidence, ( scared of having an accident at work) after taking over the counter remedies. Had many test, cameras here and there. My colon has become overstretched with pockets, due to the chronic constipation. I think the side effects of constipation are so depressing, Insomnia, back problems, lack of confidence, acid reflux, chronic pain in tummy when distended , all these things made worse by the menopause, I have been taking Prucalopride for a number of years, and yes your body does seem to become immune to it, it doesnt work well for me to be honest, my tummy often becomes so full , heavy and ready to explode, I also take peppermint capsules,soothing and slippery elm for the acid reflux, probiotic, walk my dog daily, work full time so on the go , try to keep happy, but it sounds dramatic but it is a daily struggle, fed up with it, and the constant fat belly, water retention, fuzzy head thanks for reading ,

  8. Elicia January 3, 2018 at 8:49 pm #

    Hi Folks, I have been taking Resotran 2 mg (Resolor) for one year now and it has helped me when nothing else would. I had spine surgery and the doctor damaged the spinal cord in such a way that it affected the motility of my colon among other issues. I also use aloe vera and magnesium to help move things along. I take the Restrain every evening around 5 pm. I am wondering if anyone has experience with taking it at another time that would be more effective. I know the drug manufacturers says it doesn’t matter. But maybe someone experimented and found a better time. Would early morning on an empty stomach be better? How long does it take for a bowel movement for folks after taking it. It usually works for me by early morning after first cup of hot coffee but sometimes not. That is why I am asking as it doesn’t seem as effective. Sometimes a simple glycerin suppository helps.
    Also, being in USA, I have to get it sent to me from Canada. Does anyone know of a Toronto MD who I could see? MY USA MD is moving away. Thanks, Elicia

  9. Alicia February 5, 2018 at 9:36 am #

    Came across your blog and l recently started taking resolor and considering stopping it all together. I get tummy ache and l literally have to run to the bathroom every 20mins because of diarrhoea. I can’t even risk a fart unless l am sitting on the toilet. The constant tummy pain is crazy. I feel like being constipated is better than a painful bottom from constantly running to the toilet

  10. Sushma March 8, 2018 at 8:47 am #


    I read all of ur posts from starting till the last one , I have started taking resolor only from yesterday aft taking it immediately aft 2 hours I had loose stools and again n again some 4 times . This is not good I feel I mean how am I supposed to take this tab and go out if I keep having loose stools . I had to cancel important things coz of this . I am having constipation issues only since 1 year and it was not chronic only since 5-6 months it’s become hard cant pass without laxatives . But continuing resolor am not sure as it gives me loose stools n bad migraine for days together with jus 1mg of it

  11. Kay May 5, 2018 at 11:24 pm #

    in response to your first post about the whole “diagnosis stage” and testing you had done – how are your other digestive issues now since you got your constipation under control? ie: do you still have food intolerances? if not, how did you cure them? were they caused by the constipation, and if so how??

    i ask becuase i suffer from all the same things you did in that first post, and have bee on Resotran but all my pains and food intollerances still happen (even with daily bowel movements)… any tips would be appreciated!

  12. Anto July 15, 2018 at 8:39 am #

    Love to hear replies

  13. Anto July 15, 2018 at 8:40 am #

    Love to hear replies. Love this blog.

  14. Dora Mortimer Heath July 21, 2018 at 7:10 am #

    Researching Resolor to discuss with my Gastro doctor. I have Celiac Disease and Gastroparesis. I am 54 years old and had a complete hysterectomy April 3, 2018.
    The Bloating, Gas and Constipation and Nausea have gotten worse since the hysterectomy. I have been using Dulcolax ,
    Stool Softners, Phazyme, heat pads for my stomach area and ice packs for lower back.
    I am concern about staying sick with Nausea and Migraine. Please advise.
    Thank You-D. HEATH

  15. Ryan August 22, 2018 at 3:00 am #

    Hello Kate,I am from China, I’ve just stumbled across your blog and thank you very much for your share,it is very useful. I am using Resolor now for once a week(1mg), and it works well for me just right now. are you still using this resolor now ? i am worried it wont work well for long time . And is there any sideeffect of this pill? Hope to get your reply.Thanks!

    • kate4health August 27, 2018 at 7:42 am #

      Hi Ryan,
      I’m so glad you find my site useful!
      I still take Resolor and it still works wonders for me. Resolor doesn’t stop working. The body will always use what it needs to replace the lack of serotonin in the body. If you ever find it’s not as effect (which has happened to me in the past) it is often down to diet, stress or lack of exercise.

      With regards to side effects I don’t get any.

      I hope that helps
      All the Kate

    • Kate December 12, 2019 at 5:09 pm #

      Hi There Yes it still works for me. I have been taking it for 5 years now.

  16. Fran August 25, 2018 at 7:33 pm #

    Hi Again Kate,

    I just wondered how prucalopride is working for you now? I’ve been taking it for a year now and have a couple of issues which I think are caused by it. I wake up very early and my stomach in cramps because I’m hungry (despite having something to eat before bed) and also my hair seems to have been falling out since I started. Did you or do you experience either of these please? Has your weight stabilised too? Mine started going up which was concerning me!

  17. Fran August 27, 2018 at 7:17 am #

    Hi Again Kate,

    I just wondered how prucalopride is working for you now? I’ve been taking it for a year now and have a couple of issues which I think are caused by it. I wake up very early and my stomach in cramps because I’m hungry (despite having something to eat before bed) and also my hair seems to have been falling out since I started. Did you or do you experience either of these please? Has your weight stabilised too?

    • kate4health August 27, 2018 at 7:36 am #

      Hi Fran, I haven’t had any of these symptoms. I do get hungrier on it but that’s because it speeds up your digestion and as a result your metabolism. My weight is much easier to manage I fund too.

      I would see a doctor about your falling out, you may be lacking a nutrient.

      I hope that helps ?

      All the Kate

      • Fran August 27, 2018 at 12:33 pm #

        Thanks Kate

  18. Carly September 23, 2018 at 11:56 pm #

    Hi Kate omg thanks for your blog
    How many mg per day are you on?

    I’m on 1 atm but despite cutting down on gluten and eating only fish and chicken with loads of veg
    my stools are still hard ?
    I walk a mike each day pelvic floor exercises lots of water a bit of yoga flaxseeds ( 1tsp)
    I’m so fed up
    Can you give me some of your amazing thoughts!

    • kate4health January 12, 2019 at 9:52 am #

      Hi Carly,

      Apologies for the (extremely) delayed reply. I have taken a little break from blogging but am now back to it.

      I’m so glad you enjoy my blog!

      I’m on 2mg of Resolor. I so sorry you feel uncomfortable it’s the worst feeling ever. I know you have probably heard this a thousand times but please make sure you are drinking enough water; at least 2 liters a day (that can include coffee, tea etc.). It’s a little difficult for me to give you accurate advice as I don’t know what you are eating on a regular basis. However, if you are eating meat often this can cause constipation. It does for me, I only eat meat once a week and the rest of the week will be fish. If that is not the case try taking a probiotic with lactobacillus acidophilus – I wrote a post on probiotics ‘Probiotics Are They Really Worth It?‘, this will help add good microbes to your gut and help. You could also try taking a digestive enzyme with peppermint oil to help break your food down and keep things moving.

      I hope this helps

  19. Anne Rooney October 2, 2018 at 11:21 pm #

    Hi Kate iv been suffering with Bowel obstructions for many years iv had Bowel cancer 15 years ago had left hem half Bowel removed I’m suffering terrible doctor has given Resolor iv been taking it 4 days now i normally take laxatives but doctor said not to take . I’m bit concerned as I haven’t had BM for 5days I’m worried I may have another blockage should I give it more time to see what happens thank you Anne ?

  20. William Butler October 31, 2018 at 10:02 pm #


    Thanks for the excellent review of prucalopride. I’m wondering if it is still working well for you after all this time? Is it just as effective for you now as it was when you gave your 4 month update? How is your quality of life now? Is the chronic constipation largely under control?

    • kate4health January 12, 2019 at 9:37 am #

      Hi William,

      Yes my chronic constipation is completely under control. I still take Resolor prucalopride and I can’t remember the last time I was chronically constipated. I think it’s been about 3 years now since I haven’t taken a laxative. I manage my digestion through diet and exercise. I’m in the midst of writing an update on taking prucalopride for 5 years. So stay tuned :)

  21. Lisa November 15, 2018 at 7:10 pm #

    Started resolor today and for the first time in years I have had a good bowel movement. I have colonic inertia, acid reflux, oesophagitis, gastritis, a small hiatal hernia and problems at the terminal ilium ( the junction between the large and small intestine). It seems, from my research, that this drug is a good one for targeting both upper and lower gastro intestinal disorders. I’m not sure if my results from colonoscopy will come back as Crohn’s disease, in which case I will have to discontinue with it, but I hope not. I follow a low fodmap diet and am gluten and lactose free. Resolor contains lactose, but only a minuscule amount. Thanks for the blog.

    • kate4health January 12, 2019 at 9:27 am #

      Hi Lisa!

      So glad to hear you have found something that works for you! Wishing you lots of luck that your colonoscopy comes back clear for Crohn’s disease. Keep us posted :)

  22. Anna March 1, 2019 at 11:59 pm #

    Thank you for all this info!
    Your posts and these comments are so informative.
    I started resolor today, decided to have a jump on what my future might look like.
    I’m excited about your 5 year update since my biggest fear concerning resolor is any possible damage or immunity over time.
    Tonight was rough, very strong nausea with vomiting, dizziness, headache and brain fog. Since I go to uni I hope it won’t interfere too much with my school work.
    Now, I’ve been chronically and severely constipated for 5 years, since I was 20 (feels like a lifetime)..
    For 4 years I didn’t really get any help just had to do with a combination of natural laxatives and softeners and enemas. For about a year I’ve taken orlistat, a poor weight loss medicine which my gastroentrologist prescribed me. It worked wonders with no side effect except occasional diarrhea. I would 100 percent recommend this. However, I never reached regular, care-free bowel movements which is what we all dream of right?
    I am scared of the side effects and effectiveness of resolor, but if it allows me to finally start a regular life where I can think properly, have energy for the first time and even travel then it’s definitely worth it.
    I wonder, do you still have side effects at all? Do they affect your daily life?

    • Rachel Bender March 28, 2019 at 8:16 pm #

      Hi Anna,

      Was just wondering if you could discuss orlistat in more detail and why you stopped taking it?

      I’m 26, close to your age, dealing with v similar things. How is the Resolor going for you after a month?

      xo Rachel

  23. Becky March 31, 2019 at 9:58 pm #

    Hello there,
    I have suffered with chronic constipation for a few years now, been backwards and forwards to the doctor, had blood tests which didn’t detect anything suspicious, then went for food intolerance tests. I found I am highly dairy, egg, wheat,corn and barley intolerant (as well as a few odd things such as peas and muscles)….after cutting these out it made a difference to my digestion in the short term and then sadly it became sluggish again.
    Last week I visited my doctor again who referred me to the hospital. They have given me Resolor for a month as a trial. I had movement for 2 days (which was like magic!) but then had nothing since then (except a few small pellets yesterday).
    My main issue with the constipation is fatigue, which really gets me down. This has been a big issue for me again today, my body feels exhausted which is so frustrating. Does anyone else feel this way??
    I hope sticking with it will help and my digestion will improve soon?!

    • Kate April 6, 2019 at 7:10 am #

      Hi Becky,

      Thank you for your message.

      It could be a number of factors that are causing your constipation. It’s hard for me to give you any concrete advice as I can’t tell what you are eating, what your activity levels are and emotional state is; All of which play a role in constipation.

      It sounds to me that if the doctor’s results don’t show any underlying problems then it is most definitely related to lifestyle. The first thing I’d say is don’t stress, this will make it worse. If you eat meat reduce this. I don’t like to tell people cut anything out of their diet but I found cutting meat out really helped me. It can cause digestion to slow and create methane gas which leads to constipation, just make sure you are getting your vitamins and enough protein in your diet if you do though. Always make sure you are getting enough water this keeps the bowel hydrated and stools soft. Exercise is also great for improving digestion, so be sure to stay active even if it’s only 10min of cardio a day.

      If you haven’t been tested already maybe ask your doctor if you may have a bacterial infection. Resolor will help with the motility of the bowel but it doesn’t cure constipation if there is another underlying cause.

      I know it’s frustrating and I have been in the same situation as you, as have many others.

      I hope that helped.

      All the best

  24. Chandler Jay April 13, 2019 at 10:13 pm #

    Hi great read. I just started this only on my 2nd day. First day was just awesome within 30 mins i was running for the bowl. I had 3 perfect BMs the first day. 2nd day no bowel movement and hour 4 i got heavy painful gas in my lower bowels. Im only taking .5mg. Day 3 is soon i really hope my body adjust because this constipation has caused my SIBO.

    • Kate April 20, 2019 at 9:30 am #

      Hi Chandler,

      Thank you for your message, it can vary there are several factors that can influence it’s effectiveness diet, stress, water intake, and gut bacteria. Give it time and your body will adjust.

  25. Jan April 20, 2019 at 7:16 am #

    Hi Kate
    I’ve been taking prucalopride for a week now first thing in the morning as soon as I wake but I’m finding it is varying between 1hr and 3.5 hrs to take effect and produce a bowel movement. Have you found this varies too? I don’t feel comfortable leaving the house till I’ve emptied my bowels as it does feel quite urgent when it arrives. It’s difficult to fit this into a busy life! Just wondering if the predictability of the timing improves at all?


  26. Jan April 20, 2019 at 7:35 am #

    Hi again Kate
    Also wanted to ask if you or others have used prucalopride on a demand basis instead of every day? My consultant said to take it daily but I’m just thinking that on days when I have to leave the house early (see previous post) should I just not take it? How important is it to take it at the same time every day?
    I’m having a bowel movement every day so I guess I just might not on that day or if I do it will be similar to my pre- prucalopride BMs.

    Thanks for your help

    • Kate April 20, 2019 at 9:23 am #

      Hi Jan,

      Thank you for your message.

      I would suggest taking it everyday. The timing can vary at the begining until you adjust to it but consistency will help you gut get into a more natural rhythm. I know it can a little awkward to need the toilet when your not at home. I was the same but like most people you never know when the time is going to arise. But if it is a real worry you could try taking it before bed and see if that works.


      • Jan April 20, 2019 at 2:36 pm #

        Many many thanks Kate – just one more question – does it generally take longer to work at night then? If not then the 1hr-3.5 hrs window won’t be too practical but if I can stretch it to six hours I’d be happy! Guess I just need to try it!


        • Kate April 20, 2019 at 5:36 pm #

          Hi Jan, I’d give it a go and see how you get on, everyone is different, hopefully it works for you ?

          All the best

        • Jen October 22, 2019 at 8:19 am #

          I take mine at night – bowel movement comes every morning then after breakfast. That’s how my gastroconsultant suggested taking it

  27. Patricia April 27, 2019 at 12:56 pm #

    Thank you…this has been so helpful for me!

  28. Rachel Bender June 8, 2019 at 2:12 am #

    Hi Kate,

    I just wanted to ask you about how you were doing right before you started the prucalopride?

    I know it’s been years since you started…so you probably have wiped that time from memory.

    I am just starting tomorrow but was just wondering if people are backed up for a long time beforehand and everything is hard in there – will it still work?

    Guess I’ll just have to try it out obviously…but was just wondering what things were like for you in the time frame before taking it?

    Many thanks,

  29. Katherine Espinoza October 2, 2019 at 3:48 pm #

    is there anyone in this conversation who has found more effectiveness of prucalopride by fasting before and after taking it?
    eg. somebody has tried fasting at least 4 hours after dinner (6 pm) so taking drug at 10 pm and then fasting until 9 or 10 am in the morning?
    Read an article of a patient suggesting this as effective as recommended by a doctor expert in SIBO in US, so wonder if this can work for me?

    Please let me know, I started with this drug only 20 days ago, but it seems that effectiveness is going down the hill after second week, now I strain a lot to go to toilet. So far I have been taken it after or with breaktast around 8 am. I do eat plenty of fruit and veggies and make sure I am always hydrated but nothing seems to help out but only milk with lactose which I have drank in desesperation when I feel very constipated. I understand stress plays a huge role in all this, but how to remain calm if you see that your bowels are loosing function?

    Please let me know,



  30. Bhupinder February 23, 2020 at 7:57 am #

    Dear Kate

    I am taking Resolor 2mg since 2 months with good results. I dont want to stop it because i fear severe constipation will be back. Csn i continue Resolor as long as i want.


  31. Chrissy June 17, 2020 at 9:00 pm #

    Dear Katherine, I too have only just started Prucalopride, within the last few weeks. I had been taking it with my breakfast but it was not very successful. So I, like you, thought I’d try “fasting” before tasking it. So I am starting to take it at 10 pm. I shall have to see how things go and get back to you.

    Fingers crossed for us both!


  32. Jezzibel October 21, 2020 at 7:55 pm #


    OK. I’m prepared for backlash but be gentle. I’ve had an eating disorder for over 30 years and abused laxatives over this time. Shockingly I need 20 dulcolax to produce a bowel movement. I’ve been desperate for some time to rid myself of this – the pain and side effects are second to none. I have gastroparesis and food is still in my stomach days later. My gastro suggested Prucalopride. I tried and stopped- its a mental thing. Is it worth trying again? Will it take a little while to work given the dulco history? I want to get better. God knows I really want to get better. Your advice would be so appreciated

  33. kelly November 2, 2020 at 3:05 pm #

    Hi All, I have been taking it now for 4-5 years.
    I too can’t have a BM without it although I do take 1 x 2mg daily and a dulcalax 1 x5mg (my choice) both taken every night around 1-2 hours before I go to bed.

    I started on 1mg daily and was not given any instruction on how to take it. I tried both morning and at night.
    At night worked better as in the day I just felt starving all the time and my belly made noises. For me it worked instantly and food had and has a massive effect. Fodmap definitely is one to follow although not all of it was right for me.
    I cant eat bananas, oats or anything which slows my gut down. I stay away from any grains and as mentioned before, including oats.
    Anything which slows my BM’s down is no good for me and contradicts the medication.

    I still feel starving from the medication no matter how good my diet is.
    I have tried to get tested for hormone imbalance but nothing seems to show.
    I now take saxanda (which is meant for obese people) just to stop stuffing my face.

    Just for the record I train twice a day, strength training, I also eat very well but I’m literally scoffing my face.
    I’m just under 10 stone and 5ft 6.
    I’ve not always felt the need to stuff my face and I used to train 3 times a day.
    I hate the feeling and it’s all i think about.
    The only thing I can place it down to is the resolor (prucalopride)

    Just for info, before resolor, I was lucky to go to the toilet once a month.
    I was in so much pain physically and mentally.
    I went 3 months without a BM – that was my longest time.
    I was physically vomiting so stuffing my face is not too bad – I just have to train twice a day to prevent putting on weight.

  34. Mira April 7, 2021 at 6:42 pm #

    Hi Kate ,
    I hope your well. Thank you for your blog it’s very useful and informative. I am on a one month trial on Resolor . The first 2 weeks were amazing ! The first couple of days entering my 3rd week were not so good. I have read on your blog that it is not a laxative , so how do I know if it is working as after 1 month I have to either decided to carry on taking it or stop taking it completely. If the first couple weeks were good and the last few days have been not so good how can I decide . Is this normal do you think ? I would be grateful for your input.

    Thank you

  35. Anne Beckett April 10, 2022 at 3:39 pm #

    I am 89 and considered to outsiders very fit and healthy. I started with severe bloating when aged 30 and it progressed to bad constipation 5 years later. It was diagnosed by doctors as “nerves”! I am not even a “nervy” type. I strongly suspect my condition is hereditary. Then when I was 50 a new doctor diagnosed IBS. the constipation has just got worse through the years. I do everything recommended – drink lots of water, high fibre diet, cook at home so I know what I’m eating, exercise – you name it. But I still took up to 6 dulcolax every day. Then 18 months ago I was put on prucalopride. It was like all my Christmases had come at once. Although I found after a while that prucalopride needed 2 sennokot to help it along it was still magic for me – a completely normal lifestyle although I maintained all the good lifestyle habits mentioned above. Then, after 8 months, it suddenly stopped working. I am back to up to 6 dulcolax a day, and I have a colonic hydrotherapy treatment once a month. My lifestyle is completely inhibited. I do not know what will happen when. Is there any hope for me? Doctors are no help – frankly I don’t think they even believe me!!!

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